The phosphate salt of codeine takes place as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and somewhat soluble in alcohol. The molecular body weight is 406.37. Its molecular formulation is C18H21NO3•H3PO4 • ½ H2O, and it has the following chemical structure.

Postmarketing circumstances of respiratory despair, including fatalities, are described with usage of Promethazine in pediatric individuals less than two years of age. An array of fat-primarily based doses of Promethazine have resulted in respiratory depression in these people.

Promethazine should be made use of cautiously in individuals with heart problems or with impairment of liver purpose.

Scientific research of Promethazine formulations didn't involve sufficient figures of topics aged 65 and around to find out whether or not they reply differently from youthful subjects. Other claimed medical encounter has not recognized discrepancies in responses between the aged and young people.

Promethazine is well absorbed from your gastrointestinal tract. Clinical effects are evident inside of twenty minutes just after oral administration and generally past 4 to 6 several hours, although they may persist given that 12 hrs.

Absorption Codeine is absorbed in the gastrointestinal tract with utmost plasma concentration developing 60 minutes submit administration. The existence of the significant-Excess fat, higher-calorie food did not drastically effect the PK of codeine.

Sedation This item relieves apprehension and induces a tranquil sleep from which the patient can be effortlessly aroused.

Codeine in oral therapeutic dosage will not ordinarily exert main consequences on the cardiovascular method.

Promethazine HCl Oral Resolution must be applied during pregnancy provided that the potential profit justifies the opportunity danger to your fetus.

You are able to email the location proprietor to allow them to know you have been blocked. Be sure to contain That which you had been carrying out when this web page arrived up as well as Cloudflare Ray ID discovered at the bottom of the site.

It really is strongly recommended read more that an accurate measuring system be utilized. A pharmacist can offer an acceptable machine and can offer Recommendations for measuring the right dose.

A pharmacist can recommend an correct measuring unit and can offer Recommendations for measuring the correct dose.

Ambulatory clients must be informed to prevent partaking in these pursuits until finally it is known that they don't grow to be drowsy or dizzy from promethazine and codeine therapy. Pediatric patients really should be supervised in order to avoid possible hurt in bike Driving or in other hazardous things to do.

Promethazine is metabolized through the liver to a variety of inactive metabolites for instance sulfoxides of promethazine, N-demethylpromethazine and also other glucuronides.